The Blues travel to Stamford Bridge at 13:30 (UK) with a two-point cushion on the hosts at the WSL summit ahead of a blockbuster tie.
Both sides remain unbeaten in the WSL this season, with City’s win over West Ham United last weekend seeing us leapfrog Chelsea into first after the London side were held to a 1-1 draw by Everton.
The potential returns of Charles, Mead and Miedema would provide a welcome boost ahead of Saturday’s showdown, with the former facing her ex-employers for the first time since moving to City this summer.
The full-back has been out since our 1-1 draw with Paris Saint-Germain in late October, while Mead’s last appearance came against her former club Arsenal over one month ago.
Miedema, meanwhile, could feature for the first time this season as her recovery from a knee issue continues.
And Jeglertz confirmed the trio were back in full training on Thursday afternoon ahead travelling down to Stamford Bridge, with Rebecca Knaak also available after a heavy clash in Tuesday’s 4-1 win over Inter.
Speaking about Charles, Mead and Miedema, our Head Coach said: “All three of them were in the session today, and I hope they will be available for Saturday.
“It looks good today. We had a day off yesterday and today everybody is back.
“[It was] a good session, full of energy. I feel we are in a good place.”
On Knaak, he added: “She was back in full training. No concern about that.”
City come into the tie on the back of an impressive win at Inter, which boosted our hopes of automatic qualification for the UEFA Women’s Champions League knockout stages.
The Blues delivered a 4-1 win in Monza, with the likes of WSL top scorer Bunny Shaw rested and Lauren Hemp, Knaak and Yui Hasegawa also coming on as substitutes.
Charles, Mead and Miedema’s returns add further power to the squad, and Jeglertz is delighted by the depth and quality at his disposal.
He added: “We talk about resting players but we also talk about other players getting the opportunity to show they want to compete.
“And how important the depth is in the squad and the ones that played on Tuesday were just showing that we have an amazing squad.
“Good players no matter who I start I can definitely have players coming in and changing the game. That was so crucial for us.”